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Mount Sinai Research Finds that Heterogeneity of Liver Cancer Cells Help Explain Tumor Progression in Patients

NEW YORK (PRWEB) January 16, 2020
Many liver cancer tumors contain a highly diverse set of cells, a phenomenon known as intra-tumor heterogeneity that can significantly affect the rate at which the cancer grows, Mount Sinai researchers report. The immune system’s contribution to this heterogeneity can have major clinical implications.
In a study published in January in Nature Communications, the team reported that this heterogeneity—either within the same tumor or between different tumor regions in the same tumor nodule—appears in about 30 percent of patients with hepatocellular cancer (HCC), the most common form of liver cancer, and that some of these tumors grow rapidly by hijacking different gene networks.
“Tumors are a complex ecosystem, and we’re developing for the first time a blueprint of the different ways they can evolve in patients with liver cancer by interacting with the immune system,” says Augusto Villanueva, MD, PhD, Assistant Professor in the Liver Cancer Program at The Tisch Cancer Institute at Mount Sinai, and corresponding author of the study. “By better understanding how tumors progress, we’re learning more about how they adapt to pharmacological pressures, and how they can develop mechanisms of resistance to cancer therapies. This greater awareness will hopefully lead to the identification of biomarkers that can predict which patients will be responsive to treatment.”
Among the clinical implications associated with intra-tumor heterogeneity identified by the research team was the discovery that a single liver cancer biopsy could potentially mischaracterize a liver tumor.
“Some tumors are very homogeneous in terms of their genetic makeup and immune cell infiltration, while others are very heterogeneous,” says Dr. Villanueva. “This means that a biopsy from the same tumor could yield different information depending on where it was taken, and could thus affect clinical decision-making for the patient. That’s why our work aimed at learning how tumors evolve and the different trajectories they can take is so important to future cancer research, as well as to effectively treating the disease.”
As immunotherapy continues to transform cancer research and treatment, one of the most promising areas is liver cancer, which has become the fastest-rising malignancy in the United States in terms of incidence and mortality, responsible for 33,000 new cases annually. Two phase 2 clinical trials using PD-1 immune checkpoint inhibitors, which help the body’s immune system recognize and attack cancerous cells, have achieved unprecedented responses in humans, prompting the Food and Drug Administration to grant them accelerated approval status for second-line treatment of advanced hepatocellular cancer.
More recently, a phase 3 clinical trial combining a PD-1 immune checkpoint inhibitor with an antiangiogenic improved survival compared to the current first-line standard of care, sorafenib. Still, only about 30 percent of patients with HCC are believed to respond favorably to immune checkpoint inhibition—an outcome not uncommon with immunotherapies.
“The immune system imposes significant constraints on liver cancer evolution, and by investigating the interaction of immune cells and cancer cells at the molecular level we’re trying to predict or anticipate mechanisms of tumor resistance,” explains Bojan Losic, PhD, Associate Professor of Genetics and Genomic Sciences, Cancer Immunology Program, at Icahn School of Medicine at Mount Sinai, and lead author of the study. “Our work is particularly relevant considering the remarkable success of immune checkpoint inhibitors in some heterogeneous solid tumors.”
To understand the mechanisms that drive tumor progression on a patient-by-patient basis, the research team from Mount Sinai and other medical centers around the world performed an integrated molecular analysis of gene expression, immune activities, and DNA mutations from multiple regions of the same tumor nodule in 14 liver cancer patients. The study was the first to use single-cell RNA sequencing in multiple regions of the same tumor nodule, and was among the first to assess the contribution of the immune system to liver cancer evolution.
The Mount Sinai-led study consisted of researchers from the University of Sao Paulo School of Medicine in Brazil; the University Medical Center Hamburg-Eppendorf in Hamburg, Germany; Lausanne University Hospital CHUV in Switzerland; Universitat de Barcelona in Spain; Clinica Universidad de Navarra in Spain; Dalhousie University in Halifax, Nova Scotia; and IBM Research.
About the Mount Sinai Health SystemThe Mount Sinai Health System is New York City’s largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai’s vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report’s “Best Medical Schools”, aligned with a U.S. News & World Report’s “Honor Roll” Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report’s “Honor Roll” of top U.S. hospitals; it is one of the nation’s top 20 hospitals in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology/Neurosurgery, and Orthopedics in the 2019-2020 “Best Hospitals” issue. Mount Sinai’s Kravis Children’s Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 12th nationally for Ophthalmology, Mount Sinai St. Luke’s and Mount Sinai West are ranked 23rd nationally for Nephrology and 25th for Diabetes/Endocrinology, and Mount Sinai South Nassau is ranked 35th nationally for Urology. Mount Sinai Beth Israel, Mount Sinai St. Luke’s, Mount Sinai West, and Mount Sinai South Nassau are ranked regionally.
For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.

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First-of-Its-Kind Study Finds Newark Charters Among the Most Impactful Education Approaches Studied

Study Finds Attending Newark Charters Causes “Large” and “Sustained” Improvement for Students
Press Release – updated: Jan 15, 2020 11:21 EST

NEWARK, N.J., January 15, 2020 (Newswire.com) – The New Jersey Children’s Foundation is celebrating the release of a new study by a researcher at Boston University’s Wheelock School of Education and the Manhattan Institute. According to Associate Professor Marcus Winters, the study found that “enrollment in Newark charter schools that participate in the common enrollment system tends to lead to a large improvement in math and reading scores,” and that the effect is even larger at the city’s two largest charter school networks – KIPP Newark and North Star Academy. The study also found that “attending a Newark charter school has a larger positive effect than 80% of other educational interventions that have been recently studied using an experimental design.”
“This research presents unequivocal, scientific proof that Newark’s charter schools work and are helping children learn more, faster,” said Kyle Rosenkrans, Executive Director of the New Jersey Children’s Foundation. “For years, charter school educators have toiled to build schools that reflect the genius of their students, while the question of whether this was good for Newark children has been hotly debated among politicians, pundits, and journalists. The scientific evidence is in, and this study should end the debate over whether this has been good for children – the answer is a resounding yes,” Rosenkrans added.
The study is the first randomized control trial-like analysis attempting to measure the effect of attending Newark’s charter schools. Winters employed a gold-standard “direct assignment” design for his study that used the district’s common enrollment lottery system data to eliminate factors like parental involvement and student demographics as a potential alternative explanation for the stand-out performance of Newark’s charter schools. The author also noted that this study adds to the evidence on the effectiveness of urban charter schools to improve student learning and suggests that this effectiveness continues even as the urban charter sectors get larger.
In Newark, the charter sector has grown from educating just 7 percent of the students in 2006 to an estimated 38% in 2019 and could reach 50% in future years. Relations between the city’s district and charter schools have radically improved in recent years, but the study comes at a time when tensions have resurfaced during a recent debate over whether to close four Newark charter schools.
Key findings of the study include:
● “Enrollment in a Newark charter school that participated in the common enrollment system leads to large improvements in math and English language arts (ELA) test scores, on average.”
● “The benefits of charter school enrollment do not appear to vary meaningfully depending on a student’s race, gender, or qualification for free lunch – though these estimates are based on smaller sample sizes and are thus less precise.”
● Learning gains were even more pronounced when the study isolated students in the city’s two largest charter school networks – KIPP Newark and Uncommon Schools – North Star Academy.
● “The magnitude of the impact from attending a Newark charter school is comparable to those found in prior research on charters in Boston and Denver… “attending a Newark charter school has a larger effect than 80 percent of other educational interventions that have been studied using an experimental design,” according to a paper by Brown University Professor Matthew Kraft.
About the New Jersey Children’s Foundation:
The New Jersey Children’s Foundation is a nonprofit organization aimed at promoting a fact-based discussion about public education in Newark. Our mission is to invest in people, programs, and partnerships that will improve public education systems by putting the interests of children first. Our vision is that every child will break down the walls of inequity through the creation of high-quality public education systems. Our theory of change is that when communities are armed with accurate information about public education and given the tools to act, cities will demand great schools for every student.
# # #
Contact: Matthew Frankel, MDF Strategies,917.617.7914, Matthew@MDFStrategies.com
Source: New Jersey Children’s Foundation

Expansive Survey of More Than 450 Finance and Accounting Professionals Finds Improving Productivity, Reducing Human Error and Refocusing Staff Time on Strategic Work Are Top Expected Outcomes of Financial Automation

Exclusive Report, “The Financial Automation Imperative”, from Invoiced and CFO Dive Reveals That Difficulty Staying Competitive Is The #1 Risk Of Waiting Too Long to Adopt Financial Automation Technology; A Plurality (46%) of Respondents Expect a Possible Economic Recession To Make Adopting Financial Automation Even More Important
Press Release – updated: Jan 15, 2020 08:00 CST

AUSTIN, Texas, January 15, 2020 (Newswire.com) – A new survey of more than 450 finance and accounting professionals conducted by Invoiced and CFO Dive finds at least 50% say improving productivity, reducing human error and refocusing staff time on strategic work are the top expected outcomes of financial automation. In addition, difficulty staying competitive is cited as the #1 risk of waiting too long to adopt financial automation technology.
The study, entitled “The Financial Automation Imperative”, also reveals many new insights on perspectives, plans and priorities for financial automation such as:
Cash flow related automation technologies (Accounts Receivable and Accounts Payable) have the highest adoption levels at 49% and 47% respectively. These two areas also earned the highest satisfaction levels among those using them, indicating strong maturity relative to other categories of financial automation.
The ability to integrate with other systems is cited as the most important decision driver when considering purchasing financial automation technology.
Reporting/forecasting and accounts receivable are the top automation priorities with 45% and 44% of respondents respectively indicating those categories as high or very high priority.
The biggest challenges in adopting financial automation technology are finding vendors that meet requirements, securing budget and making time and bandwidth for implementation.
Reporting/forecasting is the category of automation most likely to see an increase in spending in 2020.
Cryptocurrency is overwhelmingly viewed as the most overhyped financial technology.
The full report can be downloaded for free here.
“This new research suggests that 2020 will be a year of acceleration in the adoption of financial automation technology,” said Jared King, Co-Founder and Chief Executive Officer for Invoiced. “The attitudes and intentions uncovered in the report show that finance and accounting professionals are set on embracing automation, but are just as interested in doing so carefully and successfully,” he added.
“While digital transformation can lead to higher productivity and therefore fewer employees, organizations that don’t adapt to the sweeping changes we see impacting all industries and professions are bound to contract in any case, leading to headcount reductions no matter what,” Robert Freedman, Editor of CFO Dive, said.
The Financial Automation Imperative study was fielded in November and December 2019 and published in January 2020. The study is based on online survey responses from 459 U.S. finance and accounting professionals.
About InvoicedInvoiced is an award-winning platform for helping businesses get paid faster, stop wasting time on collections and provide a better payment experience for customers. With thousands of customers in 92 countries and nearly $50 billion in receivables processed, Invoiced is pioneering the field of accounts receivable automation. Based in Austin, Texas, Invoiced is the #1 rated A/R automation platform on G2 Crowd, a 2020 Cloud Awards Finalist and an official member of Forbes Finance Council. For more information visit invoiced.com.
About CFO DiveCFO Dive provides in-depth journalism and insight into the most impactful news and trends shaping finance. The newsletters and website cover topics such as financial reporting, compliance, technology, risk management, leadership, and more. CFO Dive is a leading publication operated by Industry Dive. Our business journalists spark ideas and shape agendas for 7+ million decision-makers in competitive industries. Visit CFO Dive at cfodive.com.
Contact:Adam Weinroth​Chief Marketing Officer for Invoicedadam@invoiced.com(866) 380-0174
Source: Invoiced

Q4 2019 KnowBe4 Finds Security-Related and Giveaway Phishing Email Subject Lines Get the Most Clicks

KnowBe4 Q4 2019 Phishing Report Infographic

As identifying phishing attacks from legitimate emails becomes trickier, it’s more important than ever for end users to look for the red flags and think before they click. -Stu Sjouwerman, CEO, KnowBe4

TAMPA BAY, Fla. (PRWEB) January 15, 2020
KnowBe4, the provider of the world’s largest security awareness training and simulated phishing platform, revealed the results of its Q4 2019 top-clicked phishing report.
The results found that simulated phishing tests with an urgent message to check a password immediately were most effective, with 39% of users falling for it. Social media messages are another area of concern when it comes to phishing. Within the same report, KnowBe4’s top-clicked social media email subjects reveal that LinkedIn messages are the most popular at 55%, followed by Facebook at 28%.
“With more end users becoming security-minded, it’s easy to see how they fall for phishing scams related to changing or checking their passwords,” said Stu Sjouwerman, CEO, KnowBe4. “They should be especially cautious if an email seems to good to be true, such as a giveaway. As identifying phishing attacks from legitimate emails becomes trickier, it’s more important than ever for end users to look for the red flags and think before they click.”
In Q4 2019, KnowBe4 examined tens of thousands of email subject lines from simulated phishing tests. The organization also reviewed ‘in-the-wild’ email subject lines that show actual emails users received and reported to their IT departments as suspicious. The results are below.
Top 10 General Email Subjects
    Change of Password Required Immediately 26%
    Microsoft/Office 365: De-activation of Email in Process 14%
    Password Check Required Immediately 13%
    HR: Employees Raises 8%
    Dropbox: Document Shared With You 8%
    IT: Scheduled Server Maintenance – No Internet Access 7%
    Office 365: Change Your Password Immediately 6%
    Avertissement des RH au sujet de l’usage des ordinateurs personnels 6%
    Airbnb: New device login 6%
    Slack: Password Reset for Account 6%
*Capitalization and spelling are as they were in the phishing test subject line.
**Email subject lines are a combination of both simulated phishing templates created by KnowBe4 for clients, and custom tests designed by KnowBe4 customers.
When investigating ‘in-the-wild’ email subject lines, KnowBe4 found the most common throughout Q4 2019 included:
    SharePoint: Approaching SharePoint Site Storage Limit
    Microsoft: Anderson Hauck has shared a Whiteboard with you
    Office 365: Medium-severity alert: Unusual volume of file deletion
    FedEx: Correct address needed for your package delivery on [[current_date_0]]
    USPS: Your digital receipt is ready
    Twitter: Your Twitter account has been locked
    Google: Please Complete the Required Steps
    Cash App: Your Account Has Been Closed
    Coinbase: Important Please Resolve Error Now
    Would you mind taking a look at this invoice?
*Capitalization and spelling are as they were in the phishing test subject line.
**In-the-wild email subject lines represent actual emails users received and reported to their IT departments as suspicious. They are not simulated phishing test emails.
For more information on KnowBe4, visit http://www.knowbe4.com.
About KnowBe4KnowBe4, the provider of the world’s largest security awareness training and simulated phishing platform, is used by more than 30,000 organizations around the globe. Founded by IT and data security specialist Stu Sjouwerman, KnowBe4 helps organizations address the human element of security by raising awareness about ransomware, CEO fraud and other social engineering tactics through a new-school approach to awareness training on security. Kevin Mitnick, an internationally recognized cybersecurity specialist and KnowBe4’s Chief Hacking Officer, helped design the KnowBe4 training based on his well-documented social engineering tactics. Tens of thousands of organizations rely on KnowBe4 to mobilize their end users as the last line of defense.

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F. G. Carroll's New Book 'Chloe, the Wiener Dog' is a Touching Story of a Dog That Finds Her New Forever Home in a Loving Family

Recent release “Chloe, the Wiener Dog” from Covenant Books author F. G. Carroll is a well-written children’s narrative about Chloe, a dog that worries about finding her future home and family.
Press Release – updated: Jan 15, 2020 06:00 EST

NEW YORK, January 15, 2020 (Newswire.com) – F. G. Carroll, a retiree, passionate author, and pet owner from Lynchburg, Virginia, has completed her new book, “Chloe, the Wiener Dog”: an exquisite tale that follows the journey of Chloe the wiener dog through loneliness and hope as she yearns for a place to be adopted and loved.
Carroll shares, “This book is based on a true story of the life and adventures of a chocolate-colored wiener dog named Chloe. As a puppy, Chloe worried she may never find her forever home. She had seen her three siblings adopted out and would hide herself, trembling in fear each time a potential adopter came to the house. This book tells how Chloe did find her forever home with a single mom and her three children. Chloe’s high-spirited, adventurous, full-of-life presence in the home launched a new beginning for this family. Their love of Chloe, and later her two wiener pups, taught the family that love and devotion of family members to each other is the most important thing on Earth, truly one of life’s greatest blessings.”
Published by Covenant Books of Murrells Inlet, South Carolina, F. G. Carroll’s new book is an enchanting masterpiece that exudes with compassion for animals all over the world that need love, care, and a place to call home.
Follow Chloe the dog in her trail from being a worrisome dog to becoming the most adorable pet to an extraordinary family.
Readers can purchase “Chloe, the Wiener Dog” at bookstores everywhere or online at the Apple iTunes Store, Amazon, or Barnes & Noble.
Covenant Books is an international Christian owned and operated publishing house based in Murrells Inlet, South Carolina. Covenant Books specializes in all genres of work which appeal to the Christian market. For additional information or media inquiries, contact Covenant Books at 843-507-8373.​
Source: Covenant Books

New Orleans SEO Meetup Finds a New Home at Search Influence

“We look forward to further developing relationships in our marketing community. This meetup is not just about SEO; it’s about creating open lines of communication and sharing between agencies and in-house marketers,” Paula French

NEW ORLEANS (PRWEB) January 15, 2020
Local digital marketing agency Search Influence is reviving the New Orleans SEO Meetup group. The first event will be hosted at Search Influence’s Central City office on Tuesday, January 28. This local meetup is free and open to those interested in search engine optimization and its role in digital advertising. All levels and backgrounds are encouraged to attend—from business owners, marketing professionals and students to SEO experts and novices.
“In the time since we started Search Influence in 2006, SEO and digital marketing in New Orleans have come a long, long way,” said Search Influence CEO Will Scott. “In 2006, there were a mere handful of SEO practitioners. There is now a thriving community of agencies, consultants and in-house marketers. We are excited to bring this group together and explore how we can all learn, grow and optimize our potential.”
Meetups are planned to be held quarterly and will serve as a space for networking and sharing industry news. Cory Agular, Digital Marketing Analyst and SEO Specialist, will lead January’s presentation: 2020 & Beyond: Trends in Local SEO. Light refreshments will be served prior to the presentation.
“We look forward to further developing relationships in our marketing community. This meetup is not just about SEO; it’s about creating open lines of communication and sharing between agencies and in-house marketers,” Paula French shared when asked about the goal for ongoing meetups. French is the Director of Sales and Marketing at Search Influence and is excited to help reboot this local meetup.
WHO: Search Influence
WHAT: New Orleans SEO Meetup
WHEN: Tuesday, January 25, 2020, 5:30 – 7:00 p.m.
WHERE: Search Influence’s address is 1610 Oretha Castle Haley Blvd., New Orleans, LA 70113 and can be reached at (504) 208-3900.
HOW: Advance registration is recommended:https://www.meetup.com/New-Orleans-SEO-Search-Engine-Optimization-Meetup/events/267542830/
Search Influence is a digital marketing based in New Orleans that serves local and national clients. With ROI-focused marketing strategies that help optimize the potential of each client, Search Influence offers search engine optimization, paid digital advertising, social media marketing and other made-to-measure strategies that elevate a company’s connection with their clients.

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HNTB finds Americans pay an average of less than $25 a month to maintain the roadways and bridges essential to mobility and the nation’s vitality

WASHINGTON (PRWEB) January 13, 2020
American families pony up thousands of dollars a year to use critical services such as electricity, water and broadband, but an analysis of available data by HNTB Corporation shows that, on average, families pay far less for the critical transportation network that powers economies, strengthens communities and improves quality of life.
On average, American drivers pay just $274.69 annually in gas taxes (federal + state taxes) at the pump, the primary source of funding for the upkeep and improvement of U.S. roads and bridges. Compared to other critical public services, the cost for their transportation systems lags far behind. Household expenses for annual average electric bills in the U.S. ran $1,340 in 2017 according to the U.S. Energy Administration. Forbes reported that annual broadband internet service totaled $794.04 that year and Statista reported that a family of four paid an average annual water bill of $844.68 last year. Individually, Americans’ mobile phone bills average nearly $100 a month or $1,200 per year, according to bill pay service Doxo.
“Think of it this way: the bills we pay monthly for critical services like electricity and water largely go to the utility companies and municipalities that provide these services,” said John Barton, senior vice president and national DOT practice leader for HNTB. “That is not so when it comes to transportation. Transportation is a utility and should be viewed as such. Mobility providers—the governments that build and maintain roadways, bridges, paths and transit systems so we can get to work or school, feed our families, supply our homes and enjoy our communities—see only a fraction of what Americans pay on average at the pump to deliver such an essential service. Typically, less than 20% of what we pay at the pump actually goes to fund our transportation system.”
“The low fuel taxes we pay are simply not enough to maintain our systems, let alone build or improve capacity,” explained Barton.
Looking for additional transportation revenue now, dozens of states across the country are raising gas taxes to help fund mounting transportation infrastructure needs and plan for the future. Even with those taxes, annual vehicle registration and other fees, funding continues to fall short as more efficient automobile engines use less gas and electric vehicles, which are quickly increasing in number, use none.
Conversely, the federal government hasn’t raised its gas tax since 1993, and the highway trust fund is woefully underfunded.
“Congress needs to think differently, think big and pass a long-term sustainable reauthorization package for surface transportation funding. It can step up communications efforts that educate Americans about the important utility of our roadways and other ways to pay for them,” Barton said. “A higher federal gas tax indexed to inflation can help quickly, but new ideas are needed, too. Mobility is vital to daily life—getting to work, school, recreation, healthcare, the grocery store, grandma’s house, the airport, moving the products and services we all consume each day—and it deserves investment levels that recognize that.”
About the NumbersHNTB reviewed state and federal gas tax data from the American Road and Transportation Builders Association and calculated average gas tax by reviewing most recent (2017) data from the Federal Highway Administration that showed average miles driven in each state, dividing it by the average 2016 miles per gallon for U.S. cars and trucks as reported by the Environmental Protection Agency and multiplying it by the average total state and federal gas tax.
Infographic available here: http://www.hntb.com/wp-content/uploads/2020/01/GasTax_Infographic.pdf
About HNTBHNTB Corporation is an employee-owned infrastructure firm serving public and private owners and contractors. With 105 years of service in the United States, HNTB understands the life cycle of infrastructure and addresses clients’ most complex technical, financial and operational challenges. Professionals nationwide deliver a full range of infrastructure-related services, including award-winning planning, design, and program and construction management. For more information, visit http://www.hntb.com, or follow HNTB on LinkedIn, Twitter, Facebook or Instagram.

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